MONDAY, March 12, 2018 -- Older adults who are sleepy during the day might have harmful plaque building in their brain that is a sign of impending Alzheimer's disease, researchers report.
A hallmark of Alzheimer's is the accumulation of a protein in the brain called beta-amyloid. It's believed that one benefit of sleep is to clear beta-amyloid, and poor sleep might allow it to build up, the authors of the new study pointed out.
WEDNESDAY, Feb. 14, 2018 -- Brain plaques believed to contribute to Alzheimer's disease melt away in mice when robbed of a key enzyme, researchers report.
And the rodents' intellectual function actually improved as their amyloid plaques dissolved from lack of beta-secretase (BACE1), an enzyme critical in the formation of the plaques, said senior researcher Riqiang Yan. He is vice chair of neuroscience with the Cleveland Clinic Lerner Research Institute.